LARANJA-AZEDA
Informações
- Nome popular: laranja-azeda
- Nome científico: Citrus aurantium L.
- Aroma: O aroma de Citrus aurantium L., também conhecido como óleo de laranja kunzite, é cítrico refrescante e revigorante
- Estudos com propriedades confirmadas: 23
Por favor, leia com atenção!
Os óleos essenciais são substâncias muito concentradas que, se utilizadas de forma errada, podem trazer malefícios. Por esta razão, sua indicação deve sempre ser feita por um profissional de saúde qualificado. Nenhum conteúdo desta página deve ser entendido como uma indicação de uso.
Antes de começar a usar esta ou qualquer página da nossa base de conhecimento sobre óleos essenciais, por favor, leia atentamente as orientações e termos de uso na página uso da base de conhecimento, onde você obterá informações sobre como estes estudos foram encontrados, classificados e outros dados relevantes.
Propriedades
A seguir, você encontra a lista de propriedades e funções do óleo essencial de laranja-azeda, que foram comprovadas por estudos científicos. Para obter mais informações sobre cada propriedade, clique em seu nome. Por favor, tenha em mente que os resultados apresentados podem incluir não somente o uso humano, mas também veterinário, ambiental e de análise bioquímica.
Durante as nossas consultas agregamos principalmente dois tipos de estudos: randomizados controlados e revisões sistemáticas. No entanto, é provável que você encontre outros tipos de estudos nesta lista devido ao processo de classificação, conforme as orientações de uso da base de conhecimento.
Citrus essential oils and four enantiomeric pinenes against Culex pipiens (Diptera: Culicidae).
Autores: Antonios Michaelakis, Dimitrios Papachristos, Athanasios Kimbaris, George Koliopoulos, Athanasios Giatropoulos, Moschos G Polissiou | Ano: 2009 | Database: pubmed
Resumo: The aim of this study was to evaluate the toxicity of pinenes (enantiomers of alpha- and beta-) and essential oils from Greek plants of the Rutaceae family against the mosquito larvae of Culex pipiens (Diptera: Culicidae). Essential oils were isolated by hydrodistillation from fruit peel of orange (Citrus sinensis L.), lemon (Citrus limon L.), and bitter orange (Citrus aurantium L.). The chemical composition was determined by gas chromatography/mass spectrometry (GC/MS) analysis. Citrus essential oils contained in high proportion limonene and in lower quantities p-menthane molecules and pinenes. The insecticidal action of these essential oils and enantiomers of their pinenes on mosquito larvae was evaluated. Plant essential oils exhibited strong toxicity against larvae with the LC(50) values ranging from 30.1 (lemon) to 51.5 mg/L (orange) depending on Citrus species and their composition. Finally, the LC(50) value of pinenes ranging from 36.53 to 66.52 mg/L indicated an enantioselective toxicity only for the beta-pinene enantiomer.
Resultados: N/A
Conclusão: N/A
Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial.
Autores: Seo Yeon Choi, Purum Kang, Hui Su Lee, Geun Hee Seol | Ano: 2014 | Database: pubmed
Resumo: This study aimed to investigate the effects of inhalation of the essential oil of Citrus aurantium L. var. amara (neroli oil) on menopausal symptoms, stress, and estrogen in postmenopausal women. Sixty-three healthy postmenopausal women were randomized to inhale 0.1% or 0.5% neroli oil or almond oil (control) for 5 minutes twice daily for 5 days. Menopause-related symptoms, as determined by the Menopause-Specific Quality of Life Questionnaire (MENQOL); sexual desire visual analog scale (VAS); serum cortisol and estrogen concentrations, blood pressure, pulse, and stress VAS, were measured before and after inhalation. Compared with the control group, the two neroli oil groups showed significant improvements in the physical domain score of the MENQOL and in sexual desire. Systolic blood pressure was significantly lower in the group inhaling 0.5% neroli oil than in the control group. Compared with the control group, the two neroli oil groups showed significantly lower diastolic blood pressure and tended to improve pulse rate and serum cortisol and estrogen concentrations. These findings indicate that inhalation of neroli oil helps relieve menopausal symptoms, increase sexual desire, and reduce blood pressure in postmenopausal women. Neroli oil may have potential as an effective intervention to reduce stress and improve the endocrine system.
Resultados: N/A
Conclusão: N/A
Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial.
Autores: Seo Yeon Choi, Purum Kang, Hui Su Lee, Geun Hee Seol | Ano: 2014 | Database: pubmed
Resumo: This study aimed to investigate the effects of inhalation of the essential oil of Citrus aurantium L. var. amara (neroli oil) on menopausal symptoms, stress, and estrogen in postmenopausal women. Sixty-three healthy postmenopausal women were randomized to inhale 0.1% or 0.5% neroli oil or almond oil (control) for 5 minutes twice daily for 5 days. Menopause-related symptoms, as determined by the Menopause-Specific Quality of Life Questionnaire (MENQOL); sexual desire visual analog scale (VAS); serum cortisol and estrogen concentrations, blood pressure, pulse, and stress VAS, were measured before and after inhalation. Compared with the control group, the two neroli oil groups showed significant improvements in the physical domain score of the MENQOL and in sexual desire. Systolic blood pressure was significantly lower in the group inhaling 0.5% neroli oil than in the control group. Compared with the control group, the two neroli oil groups showed significantly lower diastolic blood pressure and tended to improve pulse rate and serum cortisol and estrogen concentrations. These findings indicate that inhalation of neroli oil helps relieve menopausal symptoms, increase sexual desire, and reduce blood pressure in postmenopausal women. Neroli oil may have potential as an effective intervention to reduce stress and improve the endocrine system.
Resultados: N/A
Conclusão: N/A
Effects of the essential oil from Citrus aurantium L. in experimental anxiety models in mice.
Autores: Aline de Moraes Pultrini, Luciane Almeida Galindo, Mirtes Costa | Ano: 2006 | Database: pubmed
Resumo: Citrus aurantium L. is popularly used to treat anxiety, among other indications suggesting central nervous system action. Previous studies showed anxiolytic effect in the essential oil from peel in mice evaluated on the elevated plus maze [Carvalho-Freitas, M.I.R., Costa, M., 2002. Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Biological and Pharmaceutical Bulletin 25, 1629-1633.]. In order to better characterize the activity of the essential oil, it was evaluated in two other experimental models: the light-dark box and the marble-burying test, respectively related to generalized anxiety disorder and to obsessive compulsive disorder. Mice were treated acutely by oral route 30 min (single dose) or once a day for 15 days (repeated doses) before experimental procedures. In light-dark box test, single treatment with essential oil augmented the time spent by mice in the light chamber and the number of transitions between the two compartments. There were no observed alterations in the parameters evaluated in light-dark box after repeated treatment. Otherwise, single and repeated treatments with essential oil were able to suppress marble-burying behavior. At effective doses in the behavioral tests, mice showed no impairment on rotarod procedure after both single and repeated treatments with essential oil, denoting absence of motor deficit. Results observed in marble-burying test, related to obsessive compulsive disorder, appear more consistent than those observed in light-dark box.
Resultados: N/A
Conclusão: N/A
Anti-inflammatory Effect of Essential Oil from Citrus aurantium L. var. amara Engl.
Autores: Chun-Yan Shen, Jian-Guo Jiang, Wei Zhu, Qin Ou-Yang | Ano: 2017 | Database: pubmed
Resumo: Essential oil has been popularly used as an alternative for the treatment of inflammation. The bioactivities of essential oil from blossoms of Citrus aurantium L. var. amara Engl (CAVAO) showed greater anti-inflammation potential than that of antioxidant, anticancer, and 3T3-L1 proliferation inhibition. CAVAO (250 μg/mL) significantly inhibited production of nitric oxide (NO) (99.54 ± 2.81%), interleukin-6 (IL-6) (98.11 ± 1.62%), tumor necrosis factor-α (TNF-α) (41.84 ± 1.52%), and interleukin-1β (IL-1β) (56.09 ± 2.21%) as well as their gene expression level. CAVAO also markedly decreased the expression levels of cyclooxygenase-2 (COX-2) gene and protein. Furthermore, CAVAO inhibited nuclear factor-κB (NF-κB) activation, which was justified by the inhibitory effect on NF-κB nuclear translocation, IκBα phosphorylation and degradation, and phosphorylation-dependent IκB kinase activation in RAW264.7 cells stimulated with lipopolysaccharides. CAVAO also suppressed the phosphorylation of c-Jun N-terminal kinase (JNK) and p38, indicating that mitogen-activated protein kinase (MAPK) signaling pathways were also blocked. The major constituents of CAVAO were characterized as linalool (64.6 ± 0.04%), α-terpineol (7.61 ± 0.03%), (R)-limonene (6.15 ± 0.04%), and linalyl acetate (5.02 ± 0.03%), which might be responsible for its observed anti-inflammation activity. It is concluded that CAVAO has great potential to be developed into a functional food for the treatment of inflammatory-associated diseases.
Resultados: N/A
Conclusão: N/A
Anti-inflammatory Effect of Essential Oil from Citrus aurantium L. var. amara Engl.
Autores: Chun-Yan Shen, Jian-Guo Jiang, Wei Zhu, Qin Ou-Yang | Ano: 2017 | Database: pubmed
Resumo: Essential oil has been popularly used as an alternative for the treatment of inflammation. The bioactivities of essential oil from blossoms of Citrus aurantium L. var. amara Engl (CAVAO) showed greater anti-inflammation potential than that of antioxidant, anticancer, and 3T3-L1 proliferation inhibition. CAVAO (250 μg/mL) significantly inhibited production of nitric oxide (NO) (99.54 ± 2.81%), interleukin-6 (IL-6) (98.11 ± 1.62%), tumor necrosis factor-α (TNF-α) (41.84 ± 1.52%), and interleukin-1β (IL-1β) (56.09 ± 2.21%) as well as their gene expression level. CAVAO also markedly decreased the expression levels of cyclooxygenase-2 (COX-2) gene and protein. Furthermore, CAVAO inhibited nuclear factor-κB (NF-κB) activation, which was justified by the inhibitory effect on NF-κB nuclear translocation, IκBα phosphorylation and degradation, and phosphorylation-dependent IκB kinase activation in RAW264.7 cells stimulated with lipopolysaccharides. CAVAO also suppressed the phosphorylation of c-Jun N-terminal kinase (JNK) and p38, indicating that mitogen-activated protein kinase (MAPK) signaling pathways were also blocked. The major constituents of CAVAO were characterized as linalool (64.6 ± 0.04%), α-terpineol (7.61 ± 0.03%), (R)-limonene (6.15 ± 0.04%), and linalyl acetate (5.02 ± 0.03%), which might be responsible for its observed anti-inflammation activity. It is concluded that CAVAO has great potential to be developed into a functional food for the treatment of inflammatory-associated diseases.
Resultados: N/A
Conclusão: N/A
An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent.
Autores: Ipek Suntar, Haroon Khan, Seema Patel, Rita Celano, Luca Rastrelli | Ano: 2018 | Database: pubmed
Resumo: Citrus aurantium L. (Rutaceae), commonly known as bitter orange, possesses multiple therapeutic potentials. These biological credentials include anticancer, antianxiety, antiobesity, antibacterial, antioxidant, pesticidal, and antidiabetic activities. The essential oil of C. aurantium was reported to display marked pharmacological effects and great variation in chemical composition depending on growing locations but mostly contained limonene, linalool, and β-myrcene. Phytochemically, C. aurantium is rich in p-synephrine, an alkaloid, and many health-giving secondary metabolites such as flavonoids. Animal studies have demonstrated a low affinity of p-synephrine for adrenergic receptors and an even lower affinity in human models. The present review focuses on the different biological activities of the C. aurantium in animal and human models in the form of extract and its pure secondary metabolites. Finally, it is concluded that both the extract and isolated compounds have no unwanted effects in human at therapeutic doses and, therefore, can confidently be used in various dietary formulations.
Resultados: N/A
Conclusão: N/A
Characterization of essential oil from Citrus aurantium L. flowers: antimicrobial and antioxidant activities.
Autores: Anis Ben Hsouna, Naceur Hamdi, Nihed Ben Halima, Slim Abdelkafi | Ano: 2013 | Database: pubmed
Resumo: Citrus aurantium L. essential oil is commonly used as a flavouring agent. In the present study, the essential oil of fresh Citrus aurantium L. (CaEO) flowers cultivated in North East of Tunisia (Nabeul) was analyzed by GC-FID and GC-MS. 33 compounds were identified, representing 99% of the total oil. Limonene (27.5%) was the main component followed by E-nerolidol (17.5%), α-terpineol (14%), α-terpinyl acetate (11.7%) and E. E-farnesol (8%). The antimicrobial activity of the CaEO was evaluated against a panel of 13 bacteria and 8 fungal strains using agar diffusion and broth microdilution methods. Results have shown that the CaEO exhibited moderate to strong antimicrobial activity against the tested species. The investigation of the mode of action of the CaEO by the time-kill curve showed a drastic bactericidal effect after 5 min using a concentration of 624 μg/ml. The antioxidant activities of the CaEO were assayed by DPPH and beta carotene tests. Results showed that CaEO displayed an excellent DPPH scavenging ability with an IC₅₀ of 1.8 μg/ml and a strong Beta-carotene bleaching inhibition after 120 min of incubation with an IC₅₀ of 15.3 μg/ml. The results suggested that the CaEO possesses antimicrobial and antioxidant properties, and is therefore a potential source of active ingredients for food and pharmaceutical industry.
Resultados: N/A
Conclusão: N/A
Evaluation of antioxidant and inhibitory properties of Citrus aurantium L. on the acetylcholinesterase activity and the production of amyloid nano-bio fibrils.
Autores: Shayan Pasandideh, Amir Arasteh | Ano: 2021 | Database: pubmed
Resumo: The blossoms of Citrus aurantium are considered for the treatment of Alzheimer's disease because of their fragrant essential oils. The aim of this study was to investigate the antioxidant and inhibitory effects of Citrus aurantium extract on the acetylcholinesterase and production of amyloid nanobiofibrils from bovine serum albumin (BSA). The Citrus aurantium petals were harvested from Rasht city in northern IRAN. Chemical composition was investigated by GC-MS. The anti-Alzheimer's effects were evaluated by determining the antioxidant percentage by DPPH method and determining acetylcholinesterase activity. Congored spectroscopy was used for investigation of the inhibitory properties of the extract on the production of amyloid nanobiofibrils, and amyloid fibers was confirmed by electron microscopy. The most abundant ingredients were D-Glucuronic acid (9.53%), D-Limonene (5.54%), Linalool (2.06%), Daphnetin (3.73%), Phthalic acid (0.72%), Octadecenoic acid (3.98%), Hexadecanoic acid (2.13%), Pyrrolidinone (1.17%) and the highest antioxidant capacity was at 8 mg/ml (EC50: 2.36 mg/ml). The extract reduced the Acetylcholinesterase activity less than 47.04% (IC50: 42.8 mg/ml) and amyloid production less than 22% (EC50: 3.135). Citrus aurantium petals with inhibitory properties for the production of amyloid nanobiofibrils, can be used as a beneficial drugs for reducing side effects of Alzheimer's disease.
Resultados: N/A
Conclusão: N/A
Antioxidant and antiacetylcholinesterase activities of some commercial essential oils and their major compounds.
Autores: Smail Aazza, Badiâ Lyoussi, Maria G Miguel | Ano: 2011 | Database: pubmed
Resumo: The commercial essential oils of Citrus aurantium L., Cupressus sempervirens L., Eucalyptus globulus Labill., Foeniculum vulgare Mill. and Thymus vulgaris L., isolated by steam distillation by a company of Morocco were evaluated in terms of in vitro antioxidant activity through several methods. In vitro acetylcholinesterase inhibitory activity was also determined. Citrus limon (L.) Burm. f. oil was also studied, but it was obtained by peel expression. The best antioxidant was T. vulgaris oil, independent of the method used, mainly due to the presence of the phenolic monoterpenes thymol and carvacrol, which when studied as single compounds also presented the best activities. Concerning the acetylcholinesterase inhibition activity, E. globulus was the most effective. Nevertheless its main components 1,8-cineole and limonene were not the most active, a feature that corresponded to d-3-carene.
Resultados: N/A
Conclusão: N/A
An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent.
Autores: Ipek Suntar, Haroon Khan, Seema Patel, Rita Celano, Luca Rastrelli | Ano: 2018 | Database: pubmed
Resumo: Citrus aurantium L. (Rutaceae), commonly known as bitter orange, possesses multiple therapeutic potentials. These biological credentials include anticancer, antianxiety, antiobesity, antibacterial, antioxidant, pesticidal, and antidiabetic activities. The essential oil of C. aurantium was reported to display marked pharmacological effects and great variation in chemical composition depending on growing locations but mostly contained limonene, linalool, and β-myrcene. Phytochemically, C. aurantium is rich in p-synephrine, an alkaloid, and many health-giving secondary metabolites such as flavonoids. Animal studies have demonstrated a low affinity of p-synephrine for adrenergic receptors and an even lower affinity in human models. The present review focuses on the different biological activities of the C. aurantium in animal and human models in the form of extract and its pure secondary metabolites. Finally, it is concluded that both the extract and isolated compounds have no unwanted effects in human at therapeutic doses and, therefore, can confidently be used in various dietary formulations.
Resultados: N/A
Conclusão: N/A
Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT(1A)-receptors and reduces cholesterol after repeated oral treatment.
Autores: Celso A R A Costa, Thaís C Cury, Bruna O Cassettari, Regina K Takahira, Jorge C Flório, Mirtes Costa | Ano: 2013 | Database: pubmed
Resumo: The current treatments for anxiety disorders and depression have multiple adverse effects in addition to a delayed onset of action, which has prompted efforts to find new substances with potential activity in these disorders. Citrus aurantium was chosen based on ethnopharmacological data because traditional medicine refers to the Citrus genus as useful in diminishing the symptoms of anxiety or insomnia, and C. aurantium has more recently been proposed as an adjuvant for antidepressants. In the present work, we investigated the biological activity underlying the anxiolytic and antidepressant effects of C. aurantium essential oil (EO), the putative mechanism of the anxiolytic-like effect, and the neurochemical changes in specific brain structures of mice after acute treatment. We also monitored the mice for possible signs of toxicity after a 14-day treatment.
Resultados: The data suggest that the anxiolytic-like activity observed in the light/dark box procedure after acute (5 mg/kg) or 14-day repeated (1 mg/kg/day) dosing was mediated by the serotonergic system (5-HT(1A) receptors). Acute treatment with the EO showed no activity in the forced swim test, which is sensitive to antidepressants. A neurochemical evaluation showed no alterations in neurotransmitter levels in the cortex, the striatum, the pons, and the hypothalamus. Furthermore, no locomotor impairment or signs of toxicity or biochemical changes, except a reduction in cholesterol levels, were observed after treatment with the EO.
Conclusão: This work contributes to a better understanding of the biological activity of C. aurantium EO by characterizing the mechanism of action underlying its anxiolytic-like activity.
Synergistic potential of Citrus aurantium L. essential oil with antibiotics against Candida albicans.
Autores: Prakriti Nidhi, Rajan Rolta, Vikas Kumar, Kamal Dev, Anuradha Sourirajan | Ano: 2020 | Database: pubmed
Resumo: Citrus aurantium L. is used in traditional medicine in India for treating stomach ache, vomiting, blood pressure, dysentery, diarrhea, cardiovascular analeptic, sedative, boils and urinary tract infections. Its essential oil from fruit peels has antioxidant, antimicrobial, antifungal, antiparasitic, and anti-inflammatory activities.
Resultados: CAEO exhibited strong antifungal activity against two strains of C. albicans, with fungicidal effect. The MIC of CAEO against C. albicans strains was 0.15 - 0.31% (v/v). CAEO exhibited synergistic potential with fluconazole and amphotericin B against C. albicans and enhanced the antifungal efficacy of the clinical drugs by 8.3 to 34.4 folds. The GC-MS analysis of CAEO identified at least ten compounds, with 2-β pinene, δ-3 Carene and D-limonene as the major compounds. In silico molecular docking of the three major phytocompounds of CAEO with NMT and CYP51 revealed their potential to interact with both targets. δ-3 Carene showed best binding (Etotal of -131.13 kcal/mol) with NMT, while D-limonene exhibited highest binding energy (Etotal of -175.23 kcal/mol) with CYP51. ADME/T analysis showed that 2-β pinene, δ-3 Carene and D-limonene exhibit drug likeliness and ideal toxicity profiles for their use as drug candidates.
Conclusão: N/A
Synergistic potential of Citrus aurantium L. essential oil with antibiotics against Candida albicans.
Autores: Prakriti Nidhi, Rajan Rolta, Vikas Kumar, Kamal Dev, Anuradha Sourirajan | Ano: 2020 | Database: pubmed
Resumo: Citrus aurantium L. is used in traditional medicine in India for treating stomach ache, vomiting, blood pressure, dysentery, diarrhea, cardiovascular analeptic, sedative, boils and urinary tract infections. Its essential oil from fruit peels has antioxidant, antimicrobial, antifungal, antiparasitic, and anti-inflammatory activities.
Resultados: CAEO exhibited strong antifungal activity against two strains of C. albicans, with fungicidal effect. The MIC of CAEO against C. albicans strains was 0.15 - 0.31% (v/v). CAEO exhibited synergistic potential with fluconazole and amphotericin B against C. albicans and enhanced the antifungal efficacy of the clinical drugs by 8.3 to 34.4 folds. The GC-MS analysis of CAEO identified at least ten compounds, with 2-β pinene, δ-3 Carene and D-limonene as the major compounds. In silico molecular docking of the three major phytocompounds of CAEO with NMT and CYP51 revealed their potential to interact with both targets. δ-3 Carene showed best binding (Etotal of -131.13 kcal/mol) with NMT, while D-limonene exhibited highest binding energy (Etotal of -175.23 kcal/mol) with CYP51. ADME/T analysis showed that 2-β pinene, δ-3 Carene and D-limonene exhibit drug likeliness and ideal toxicity profiles for their use as drug candidates.
Conclusão: N/A
Chemical Compositions and Antioxidant Activities of Essential Oils, and Their Combinations, Obtained from Flavedo By-Product of Seven Cultivars of Sicilian Citrus aurantium L.
Autores: Natale Badalamenti, Maurizio Bruno, Rosario Schicchi, Anna Geraci, Mariarosaria Leporini, Luigia Gervasi, Rosa Tundis, Monica Rosa Loizzo | Ano: 2022 | Database: pubmed
Resumo: In this work, seven Citrus aurantium essential oils (EOs) derived from flavedo of cultivars 'Canaliculata', 'Consolei', 'Crispifolia', 'Fasciata', 'Foetifera', 'Listata', and 'Bizzaria' were investigated. EOs were also combined in 1:1 (v/v) ratio to identify possible synergism or antagonism of actions. GC-MS analysis was done to investigate Eos' phytochemical profiles. The antioxidant activity was studied by using a multi-target approach based on FRAP, DPPH, ABTS, and β-carotene bleaching tests. A great difference was observed in EOs' phytochemical profiles. d-limonene (33.35-89.17%) was the main monoterpene hydrocarbon, and α-Pinene, β-myrcene, and β-linalool were identified in almost all samples. Among EOs, only C3 showed high quantitative and qualitative variability in its chemical composition. The chemical diversity of EOs was also demonstrated by PCA and HCA statistical analysis. Samples C2, C4, C5, C6, and C7 were statistically similar to each other, while C1 and C3 were characterized as having a different amount of other compounds and oxygenated monoterpenes, respectively, with respect to the other EOs mentioned. The global antioxidant score (GAS) revealed that among the tested EOs, C. aurantium 'Fasciata' EO had the highest antioxidant potential, with a GAS value of -0.47, whereas among combinations, the EO obtained by mixing 'Canaliculata' + 'Bizzaria' was the most active. Comparison by theoretical and real data on inhibitory concentration (IC50) and FRAP values did not reveal any significant effect of synergism or antagonism of actions to be valid in all biological applied tests. These findings, considered together, represent an important starting point to understand which compounds are responsible for the activities and their future possible industrial application.
Resultados: N/A
Conclusão: N/A
Citrus aurantium L. bloom essential oil nanoemulsion: Synthesis, characterization, cytotoxicity, and its potential health impacts on mice.
Autores: Somayeh Navaei Shoorvarzi, Farzaneh Shahraki, Negin Shafaei, Ehsan Karimi, Ehsan Oskoueian | Ano: 2020 | Database: pubmed
Resumo: This research was performed to synthesize the Citrus aurantium L. bloom essential oil nanoemulsion (CABE-NE) and investigate its cytotoxic and apoptotic impacts on human lung (A549 cells), and further, the effects of CABE-NE on mice health parameters was determined. The obtained results demonstrated that C. aurantium bloom contained 1.2 ± 0.16% of essential oil with linalyl acetate, limonene, and α-terpineol as major compounds. The CABE-NE possessed particle size of 76.9 ± 6.11 nm, PDI of 0.19, and zeta potential of -43.5 mV. The CABE-NE indicated the cytotoxicity against A549 cells with the IC50 value of 152 µg/ml. The CABE-NE induced the overexpression of Cas-3 and triggered the apoptotic cells death. The mice gavaged daily with CABE-NE at the concentrations of 10 and 20 mg/kg body weight for 30 days did not show any remarkable histopathological alteration in the liver and kidney while exhibited enhancement in the jejunum morpho-structural architecture and hepatic antioxidant redox potential. PRACTICAL APPLICATIONS: According to the results, the produced CABE-NE drug delivery system could be considered as a promising alternative to prevent lung cancer progression and it provides a new way to enhance the therapeutic value of the plant phytochemicals.
Resultados: N/A
Conclusão: N/A
Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L.
Autores: Maria Isabel Roth Carvalho-Freitas, Mirtes Costa | Ano: 2002 | Database: pubmed
Resumo: Citrus aurantium L. is commonly used as an alternative treatment for insomnia, anxiety and epilepsy. Essential oil from peel (EOP) and hydroethanolic (70% w/v) extract (HE) from leaves were obtained. Hexanic (HF), dichloromethanic (DF) and final aqueous (AF) fractions were obtained from HE by successive partitions. Swiss male mice (35-45 g) were treated orally with 0.5 or 1.0 g/kg of these preparations 30 min before the experiments for the evaluation of the sedative/hypnotic activity (sleeping time induced by sodium pentobarbital - SPB: 40 mg/kg, i.p.), anxiolytic activity (elevated plus maze--EPM) and anticonvulsant activity (induced by pentylenetetrazole--PTZ: 85 mg/kg, sc or by maximal electroshock--MES: 50 mA, 0.11 s, corneal). The results showed that EOP (0.5 g/kg) increased the latency period of tonic seizures in both convulsing experimental models. This effect was not dose-dependent. Treatment with 1.0 g/kg increased the sleeping time induced by barbiturates and the time spent in the open arms of the EPM. Specific tests indicated that the preparation, in both doses used, did not promote deficits in general activity or motor coordination. HF and DF fractions (1.0 g/kg) did not interfere in the epileptic seizures, but were able to enhance the sleeping time induced by barbiturates. The results obtained with EOP in the anxiety model, and with EOP, HF and DF in the sedation model, are in accord with the ethnopharmacological use of Citrus aurantium L., which could be useful in primary medical care, after toxicological investigation.
Resultados: N/A
Conclusão: N/A
Evaluation of antioxidant and inhibitory properties of Citrus aurantium L. on the acetylcholinesterase activity and the production of amyloid nano-bio fibrils.
Autores: Shayan Pasandideh, Amir Arasteh | Ano: 2021 | Database: pubmed
Resumo: The blossoms of Citrus aurantium are considered for the treatment of Alzheimer's disease because of their fragrant essential oils. The aim of this study was to investigate the antioxidant and inhibitory effects of Citrus aurantium extract on the acetylcholinesterase and production of amyloid nanobiofibrils from bovine serum albumin (BSA). The Citrus aurantium petals were harvested from Rasht city in northern IRAN. Chemical composition was investigated by GC-MS. The anti-Alzheimer's effects were evaluated by determining the antioxidant percentage by DPPH method and determining acetylcholinesterase activity. Congored spectroscopy was used for investigation of the inhibitory properties of the extract on the production of amyloid nanobiofibrils, and amyloid fibers was confirmed by electron microscopy. The most abundant ingredients were D-Glucuronic acid (9.53%), D-Limonene (5.54%), Linalool (2.06%), Daphnetin (3.73%), Phthalic acid (0.72%), Octadecenoic acid (3.98%), Hexadecanoic acid (2.13%), Pyrrolidinone (1.17%) and the highest antioxidant capacity was at 8 mg/ml (EC50: 2.36 mg/ml). The extract reduced the Acetylcholinesterase activity less than 47.04% (IC50: 42.8 mg/ml) and amyloid production less than 22% (EC50: 3.135). Citrus aurantium petals with inhibitory properties for the production of amyloid nanobiofibrils, can be used as a beneficial drugs for reducing side effects of Alzheimer's disease.
Resultados: N/A
Conclusão: N/A
Citrus essential oils and four enantiomeric pinenes against Culex pipiens (Diptera: Culicidae).
Autores: Antonios Michaelakis, Dimitrios Papachristos, Athanasios Kimbaris, George Koliopoulos, Athanasios Giatropoulos, Moschos G Polissiou | Ano: 2009 | Database: pubmed
Resumo: The aim of this study was to evaluate the toxicity of pinenes (enantiomers of alpha- and beta-) and essential oils from Greek plants of the Rutaceae family against the mosquito larvae of Culex pipiens (Diptera: Culicidae). Essential oils were isolated by hydrodistillation from fruit peel of orange (Citrus sinensis L.), lemon (Citrus limon L.), and bitter orange (Citrus aurantium L.). The chemical composition was determined by gas chromatography/mass spectrometry (GC/MS) analysis. Citrus essential oils contained in high proportion limonene and in lower quantities p-menthane molecules and pinenes. The insecticidal action of these essential oils and enantiomers of their pinenes on mosquito larvae was evaluated. Plant essential oils exhibited strong toxicity against larvae with the LC(50) values ranging from 30.1 (lemon) to 51.5 mg/L (orange) depending on Citrus species and their composition. Finally, the LC(50) value of pinenes ranging from 36.53 to 66.52 mg/L indicated an enantioselective toxicity only for the beta-pinene enantiomer.
Resultados: N/A
Conclusão: N/A
Characterization of essential oil from Citrus aurantium L. flowers: antimicrobial and antioxidant activities.
Autores: Anis Ben Hsouna, Naceur Hamdi, Nihed Ben Halima, Slim Abdelkafi | Ano: 2013 | Database: pubmed
Resumo: Citrus aurantium L. essential oil is commonly used as a flavouring agent. In the present study, the essential oil of fresh Citrus aurantium L. (CaEO) flowers cultivated in North East of Tunisia (Nabeul) was analyzed by GC-FID and GC-MS. 33 compounds were identified, representing 99% of the total oil. Limonene (27.5%) was the main component followed by E-nerolidol (17.5%), α-terpineol (14%), α-terpinyl acetate (11.7%) and E. E-farnesol (8%). The antimicrobial activity of the CaEO was evaluated against a panel of 13 bacteria and 8 fungal strains using agar diffusion and broth microdilution methods. Results have shown that the CaEO exhibited moderate to strong antimicrobial activity against the tested species. The investigation of the mode of action of the CaEO by the time-kill curve showed a drastic bactericidal effect after 5 min using a concentration of 624 μg/ml. The antioxidant activities of the CaEO were assayed by DPPH and beta carotene tests. Results showed that CaEO displayed an excellent DPPH scavenging ability with an IC₅₀ of 1.8 μg/ml and a strong Beta-carotene bleaching inhibition after 120 min of incubation with an IC₅₀ of 15.3 μg/ml. The results suggested that the CaEO possesses antimicrobial and antioxidant properties, and is therefore a potential source of active ingredients for food and pharmaceutical industry.
Resultados: N/A
Conclusão: N/A
Toxic effects of six plant oils alone and in combination with controlled atmosphere on Liposcelis bostrychophila (Psocoptera: Liposcelididae).
Autores: J J Wang, J H Tsai, W Ding, Z M Zhao, L S Li | Ano: 2001 | Database: pubmed
Resumo: Six plant essential oils alone as repellent and fumigant, and in combination with the controlled atmosphere against Liposcelis bostrychophila Badonnel were assessed in the laboratory. These essential oils were extracted from the leaves of six source plants: Citrus tangerina Tanaka, Citrus aurantium L., Citrus bergamia Risso et Poiteau, Pinus sylvestris L., Cupressus funebris End]., and Eucalyptus citriodora Hook. The repellency test indicated that L. bostrychophila adults were repelled by filter paper strips treated with six essential oils. Of these essential oils, the C. funebris oil was most effective followed by that of F. sylvestris, C. tangerina, C. bergamia, and E. citriodora. The average repellency of the C. aurantium oil against L. bostrychophila adults was significantly lower than other five test oils by day 14. These essential oils had a high level of toxicity in the fumigation assay against L. bostrychophila adults at both 10 and 20 ppm. When combined with two controlled atmosphere treatments (12% CO2 + 9% O2, and 10% CO2 + 5% O2, balanced N2), the toxicity of plant oils was enhanced significantly.
Resultados: N/A
Conclusão: N/A
Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca(2+) modulation.
Autores: Purum Kang, Kang-Hyun Ryu, Jeong-Min Lee, Hyo-Keun Kim, Geun Hee Seol | Ano: 2016 | Database: pubmed
Resumo: Neroli, the essential oil of Citrus aurantium L. var. amara, is a well-characterized alleviative agent used to treat cardiovascular symptoms. However, because it has been found to have multiple effects, its mechanism of action requires further exploration. We sought to clarify the mechanism underlying the actions of neroli in mouse aorta. In aortic rings from mice precontracted with prostaglandin F2 alpha, neroli induced vasodilation. However, relaxation effect of neroli was decreased in endothelium-denuded ring or pre-incubation with the nitric oxide synthase inhibitor NG-Nitro-l-arginine-methyl ester (L-NAME). And also, neroli-induced relaxation was also partially reversed by 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ), a soluble guanylyl cyclase (sGC) inhibitor. In addition, neroli inhibited extracellular Ca(2+)-dependent, depolarization-induced contraction, an effect that was concentration dependent. Pretreatment with the non-selective cation channel blocker, Ni(2+), attenuated neroli-induced relaxation, whereas the K(+) channel blocker, tetraethylammonium chloride, had no effect. In the presence of verapamil, added to prevent Ca(2+) influx via smooth muscle voltage-gated Ca(2+) channels, neroli-induced relaxation was reduced by the ryanodine receptor (RyR) inhibitor ruthenium red. Our findings further indicate that the endothelial component of neroli-induced vasodilation is partly mediated by the NO-sGC pathway, whereas the smooth muscle component involves modulation of intracellular Ca(2+) concentration through inhibition of cation channel-mediated extracellular Ca(2+) influx and store-operated Ca(2+) release mediated by the RyR signaling pathway.
Resultados: N/A
Conclusão: N/A
Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca(2+) modulation.
Autores: Purum Kang, Kang-Hyun Ryu, Jeong-Min Lee, Hyo-Keun Kim, Geun Hee Seol | Ano: 2016 | Database: pubmed
Resumo: Neroli, the essential oil of Citrus aurantium L. var. amara, is a well-characterized alleviative agent used to treat cardiovascular symptoms. However, because it has been found to have multiple effects, its mechanism of action requires further exploration. We sought to clarify the mechanism underlying the actions of neroli in mouse aorta. In aortic rings from mice precontracted with prostaglandin F2 alpha, neroli induced vasodilation. However, relaxation effect of neroli was decreased in endothelium-denuded ring or pre-incubation with the nitric oxide synthase inhibitor NG-Nitro-l-arginine-methyl ester (L-NAME). And also, neroli-induced relaxation was also partially reversed by 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ), a soluble guanylyl cyclase (sGC) inhibitor. In addition, neroli inhibited extracellular Ca(2+)-dependent, depolarization-induced contraction, an effect that was concentration dependent. Pretreatment with the non-selective cation channel blocker, Ni(2+), attenuated neroli-induced relaxation, whereas the K(+) channel blocker, tetraethylammonium chloride, had no effect. In the presence of verapamil, added to prevent Ca(2+) influx via smooth muscle voltage-gated Ca(2+) channels, neroli-induced relaxation was reduced by the ryanodine receptor (RyR) inhibitor ruthenium red. Our findings further indicate that the endothelial component of neroli-induced vasodilation is partly mediated by the NO-sGC pathway, whereas the smooth muscle component involves modulation of intracellular Ca(2+) concentration through inhibition of cation channel-mediated extracellular Ca(2+) influx and store-operated Ca(2+) release mediated by the RyR signaling pathway.
Resultados: N/A
Conclusão: N/A
Tabela de propriedades
| Óleo Essencial | Propriedade | Confirmado | Título | Autores | Ano | Database | Link |
|---|---|---|---|---|---|---|---|
| laranja-azeda | Inseticida contra larvas de mosquito Culex pipiens | Sim | Citrus essential oils and four enantiomeric pinenes against Culex pipiens (Diptera: Culicidae). | Antonios Michaelakis, Dimitrios Papachristos, Athanasios Kimbaris, George Koliopoulos, Athanasios Giatropoulos, Moschos G Polissiou | 2009 | pubmed | N/A |
| laranja-azeda | Alívio dos sintomas da menopausa, aumento do desejo sexual e redução da pressão arterial | Sim | Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial. | Seo Yeon Choi, Purum Kang, Hui Su Lee, Geun Hee Seol | 2014 | pubmed | N/A |
| laranja-azeda | Alívio dos sintomas da menopausa, aumento do desejo sexual e redução da pressão arterial em mulheres pós-menopáusicas | Sim | Effects of Inhalation of Essential Oil of Citrus aurantium L. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial. | Seo Yeon Choi, Purum Kang, Hui Su Lee, Geun Hee Seol | 2014 | pubmed | N/A |
| laranja-azeda | Ansiolítico | Sim | Effects of the essential oil from Citrus aurantium L. in experimental anxiety models in mice. | Aline de Moraes Pultrini, Luciane Almeida Galindo, Mirtes Costa | 2006 | pubmed | N/A |
| laranja-azeda | Anti-inflamatória | Sim | Anti-inflammatory Effect of Essential Oil from Citrus aurantium L. var. amara Engl. | Chun-Yan Shen, Jian-Guo Jiang, Wei Zhu, Qin Ou-Yang | 2017 | pubmed | N/A |
| laranja-azeda | Anti-inflamatório | Sim | Anti-inflammatory Effect of Essential Oil from Citrus aurantium L. var. amara Engl. | Chun-Yan Shen, Jian-Guo Jiang, Wei Zhu, Qin Ou-Yang | 2017 | pubmed | N/A |
| laranja-azeda | Antibacteriano | Sim | An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent. | Ipek Suntar, Haroon Khan, Seema Patel, Rita Celano, Luca Rastrelli | 2018 | pubmed | N/A |
| laranja-azeda | Antimicrobiano e antioxidante | Sim | Characterization of essential oil from Citrus aurantium L. flowers: antimicrobial and antioxidant activities. | Anis Ben Hsouna, Naceur Hamdi, Nihed Ben Halima, Slim Abdelkafi | 2013 | pubmed | N/A |
| laranja-azeda | Antioxidante e inibidor da atividade da acetilcolinesterase e da produção de nanobiofibrilas amiloides | Sim | Evaluation of antioxidant and inhibitory properties of Citrus aurantium L. on the acetylcholinesterase activity and the production of amyloid nano-bio fibrils. | Shayan Pasandideh, Amir Arasteh | 2021 | pubmed | N/A |
| laranja-azeda | Antioxidante e inibidor de acetilcolinesterase | Sim | Antioxidant and antiacetylcholinesterase activities of some commercial essential oils and their major compounds. | Smail Aazza, Badiâ Lyoussi, Maria G Miguel | 2011 | pubmed | N/A |
| laranja-azeda | Antioxidante, antibacteriano, antidiabético, anticâncer, antiansiedade, pesticida e antiobesidade | Sim | An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent. | Ipek Suntar, Haroon Khan, Seema Patel, Rita Celano, Luca Rastrelli | 2018 | pubmed | N/A |
| laranja-azeda | Atividade ansiolítica | Sim | Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT(1A)-receptors and reduces cholesterol after repeated oral treatment. | Celso A R A Costa, Thaís C Cury, Bruna O Cassettari, Regina K Takahira, Jorge C Flório, Mirtes Costa | 2013 | pubmed | N/A |
| laranja-azeda | Atividade antifúngica contra Candida albicans | Sim | Synergistic potential of Citrus aurantium L. essential oil with antibiotics against Candida albicans. | Prakriti Nidhi, Rajan Rolta, Vikas Kumar, Kamal Dev, Anuradha Sourirajan | 2020 | pubmed | N/A |
| laranja-azeda | Atividade antifúngica e potencial sinérgico com fluconazol e anfotericina B contra Candida albicans | Sim | Synergistic potential of Citrus aurantium L. essential oil with antibiotics against Candida albicans. | Prakriti Nidhi, Rajan Rolta, Vikas Kumar, Kamal Dev, Anuradha Sourirajan | 2020 | pubmed | N/A |
| laranja-azeda | Atividade antioxidante | Sim | Chemical Compositions and Antioxidant Activities of Essential Oils, and Their Combinations, Obtained from Flavedo By-Product of Seven Cultivars of Sicilian Citrus aurantium L. | Natale Badalamenti, Maurizio Bruno, Rosario Schicchi, Anna Geraci, Mariarosaria Leporini, Luigia Gervasi, Rosa Tundis, Monica Rosa Loizzo | 2022 | pubmed | N/A |
| laranja-azeda | CABE-NE (nanoemulsão de óleo essencial de flor de Citrus aurantium L.) possui citotoxicidade contra células A549 e induz a morte celular apoptótica | Sim | Citrus aurantium L. bloom essential oil nanoemulsion: Synthesis, characterization, cytotoxicity, and its potential health impacts on mice. | Somayeh Navaei Shoorvarzi, Farzaneh Shahraki, Negin Shafaei, Ehsan Karimi, Ehsan Oskoueian | 2020 | pubmed | N/A |
| laranja-azeda | Efeito ansiolítico e sedativo | Sim | Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. | Maria Isabel Roth Carvalho-Freitas, Mirtes Costa | 2002 | pubmed | N/A |
| laranja-azeda | Inibidor da produção de nanobiofibrilas amiloides | Sim | Evaluation of antioxidant and inhibitory properties of Citrus aurantium L. on the acetylcholinesterase activity and the production of amyloid nano-bio fibrils. | Shayan Pasandideh, Amir Arasteh | 2021 | pubmed | N/A |
| laranja-azeda | Inseticida contra larvas de mosquitos do gênero Culex pipiens | Sim | Citrus essential oils and four enantiomeric pinenes against Culex pipiens (Diptera: Culicidae). | Antonios Michaelakis, Dimitrios Papachristos, Athanasios Kimbaris, George Koliopoulos, Athanasios Giatropoulos, Moschos G Polissiou | 2009 | pubmed | N/A |
| laranja-azeda | O CaEO apresenta atividade antimicrobiana de moderada a forte contra bactérias e fungos | Sim | Characterization of essential oil from Citrus aurantium L. flowers: antimicrobial and antioxidant activities. | Anis Ben Hsouna, Naceur Hamdi, Nihed Ben Halima, Slim Abdelkafi | 2013 | pubmed | N/A |
| laranja-azeda | Repelente contraLiposcelis bostrychophila | Sim | Toxic effects of six plant oils alone and in combination with controlled atmosphere on Liposcelis bostrychophila (Psocoptera: Liposcelididae). | J J Wang, J H Tsai, W Ding, Z M Zhao, L S Li | 2001 | pubmed | N/A |
| laranja-azeda | Vasodilatador dependente do endotélio e músculo liso | Sim | Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca(2+) modulation. | Purum Kang, Kang-Hyun Ryu, Jeong-Min Lee, Hyo-Keun Kim, Geun Hee Seol | 2016 | pubmed | N/A |
| laranja-azeda | Vasodilatação em anéis aórticos de camundongos | Sim | Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca(2+) modulation. | Purum Kang, Kang-Hyun Ryu, Jeong-Min Lee, Hyo-Keun Kim, Geun Hee Seol | 2016 | pubmed | N/A |