MIRRA
Informações
- Nome popular: Mirra
- Nome científico: Commiphora myrrha (Nees) Engl.
- Aroma: O aroma de Commiphora myrrha (Nees) Engl. é quente, doce e terroso, com notas densas e ricas. É um aroma suave e agradável, com propriedades fixadoras excelentes. Algumas pessoas o descrevem como sendo semelhante a um aroma amadeirado, com notas de especiarias e um toque de fumaça.
- Estudos com propriedades confirmadas: 25
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Antes de começar a usar esta ou qualquer página da nossa base de conhecimento sobre óleos essenciais, por favor, leia atentamente as orientações e termos de uso na página uso da base de conhecimento, onde você obterá informações sobre como estes estudos foram encontrados, classificados e outros dados relevantes.
Propriedades
A seguir, você encontra a lista de propriedades e funções do óleo essencial de mirra, que foram comprovadas por estudos científicos. Para obter mais informações sobre cada propriedade, clique em seu nome. Por favor, tenha em mente que os resultados apresentados podem incluir não somente o uso humano, mas também veterinário, ambiental e de análise bioquímica.
Durante as nossas consultas agregamos principalmente dois tipos de estudos: randomizados controlados e revisões sistemáticas. No entanto, é provável que você encontre outros tipos de estudos nesta lista devido ao processo de classificação, conforme as orientações de uso da base de conhecimento.
Components, therapeutic value and uses of myrrh.
Autores: E S H El Ashry, N Rashed, O M Salama, A Saleh | Ano: 2003 | Database: pubmed
Resumo: Occurrence, constituents and medicinal use of myrrh, obtained from the stem of different Commiphora species are reviewed. The constituents of the volatile oil, the resin and the gum are outlined in detail. Myrrh has considerable antimicrobial activity and is medicinally used in a variety of diseases.
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Components, therapeutic value and uses of myrrh.
Autores: E S H El Ashry, N Rashed, O M Salama, A Saleh | Ano: 2003 | Database: pubmed
Resumo: Occurrence, constituents and medicinal use of myrrh, obtained from the stem of different Commiphora species are reviewed. The constituents of the volatile oil, the resin and the gum are outlined in detail. Myrrh has considerable antimicrobial activity and is medicinally used in a variety of diseases.
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Myrrh: medical marvel or myth of the Magi?
Autores: Effie Y H Nomicos | Ano: 2007 | Database: pubmed
Resumo: Since antiquity, the genus Commiphora is composed of more than 200 species, and has been exploited as a natural drug to treat pain, skin infections, inflammatory conditions, diarrhea, and periodontal diseases. In more recent history, products derived from Commiphora myrrha and various other species of Commiphora are becoming recognized to possess significant antiseptic, anesthetic, and antitumor properties. Traditional practice and evidence-based research have supported that these properties are directly attributable to terpenoids (especially furanosesquiterpenes), the active compounds present in myrrh essential oil. More recently, current studies have focused on applying clinical trial methodologies to validate its use as an antineoplastic, an antiparasitic agent, and as an adjunct in healing wounds.
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Sensitivity of clinical isolates of Candida to essential oils from Burseraceae family.
Autores: Miloš Nikolic, Marija Smiljkovic, Tatjana Markovic, Ana Cirica, Jasmina Glamoclija, Dejan Markovic, Marina Sokovic | Ano: 2016 | Database: pubmed
Resumo: The aim of this study was to investigate the chemical composition and antifungal activity of four commercial essential oils from the Burseraceae family - two Boswellia carterii Flueck oils, Canarium luzonicum (Blume) A. Gray oil, and Commiphora myrrha (Nees) Engl oil, against most common Candida spp. recovered from the human oral cavity. The essential oil samples were analyzed by GC-FID and GC/MS. The analysis showed that major essential oils' components were α-pinene (23.04 % and 31.84 %), limonene (45.62 %) and curzerene (34.65 %), respectively. Minimum inhibitory (MIC) and minimum fungicidal (MFC) concentrations were determined using a microdilution standardized technique. All tested Candida spp. clinical isolates and ATCC strains showed susceptibility to tested essential oils in a dose dependent manner. The strongest antifungal activity was shown by essential oil of B. carterii, sample 2; the average MIC values ranged from 1.25 to 1.34 mg/ml, and MFC values ranged from 2.50 to 3.75 mg/ml, depending on the fungus. This study supports the possible use of essential oils from the Bursecaceae family in reduction and elimination of Candida spp. populations in patients with oral cavity fungal infections.
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The additive and synergistic antimicrobial effects of select frankincense and myrrh oils--a combination from the pharaonic pharmacopoeia.
Autores: S de Rapper, S F Van Vuuren, G P P Kamatou, A M Viljoen, E Dagne | Ano: 2012 | Database: pubmed
Resumo: The in vitro antimicrobial activity of three essential oil samples of frankincense (Boswellia rivae, Boswellia neglecta and Boswellia papyrifera) and two essential oil samples of myrrh and sweet myrrh (Commiphora guidotti and Commiphora myrrha), collected from different regions of Ethiopia, was investigated independently and in combination to determine their anti-infective properties.
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Chemical composition and antibacterial activity of selected essential oils and some of their main compounds.
Autores: Juergen Wanner, Erich Schmidt, Stefanie Bail, Leopold Jirovetz, Gerhard Buchbauer, Velizar Gochev, Tanya Girova, Teodora Atanasova, Albena Stoyanova | Ano: 2010 | Database: pubmed
Resumo: The chemical composition of essential oils of cabreuva (Myrocarpus fastigiatus Allemao, Fabaceae) from Brazil, cedarwood (Juniperus ashei, Cupressaceae) from Texas, Juniper berries (Juniperus communis L., Cupressaceae) and myrrh (Commiphora myrrha (Nees) Engl., Burseraceae) were analyzed using GC/FID and GC/MS. The antimicrobial activity of these essential oils and some of their main compounds were tested against eleven different strains of Gram-positive and Gram-negative bacteria by using agar diffusion and agar serial dilution methods. Animal and plant pathogens, food poisoning and spoilage bacteria were selected. The volatile oils exhibited considerable inhibitory effects against all tested organisms, except Pseudomonas, using both test methods. Higher activity was observed against Gram-positive strains in comparison with Gram-negative bacteria. Cabreuva oil from Brazil showed similar results, but in comparison with the other oils tested, only when higher concentrations of oil were used.
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Wound Pathogens: Investigating Antimicrobial Activity of Commercial Essential Oil Combinations against Reference Strains.
Autores: Ané Orchard, Alvaro Viljoen, Sandy van Vuuren | Ano: 2018 | Database: pubmed
Resumo: This study aimed to determine the antimicrobial activity of 247 essential oil combinations against the reference strains of wound pathogens. Essential oil combinations were investigated for antimicrobial activity against five pathogens. The minimum inhibitory concentration (MIC) assay was used and the fractional inhibitory concentration index (ΣFIC) calculated to determine interactions between selected oils. Twenty-six combinations displayed broad-spectrum antimicrobial activity against all five reference strains and several displayed synergy against more than one pathogen. The combination of Santalum austrocaledonicum (sandalwood) with Commiphora myrrha (myrrh) displayed noteworthy antimicrobial activity against all five reference strains and synergy against four (MIC values 0.03-1.00 mg/ml and ΣFIC values 0.19-1.00 mg/ml) pathogens. No antagonism was observed. Santalum spp. and Vetiveria zizanioides essential oils contributed the most to antimicrobial activity in combination. Essential oil combinations are presented as a viable option in wound therapy.
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Bactericidal activity of Myrrh extracts and two dosage forms against standard bacterial strains and multidrug-resistant clinical isolates with GC/MS profiling.
Autores: Noha Khalil, Sahar Fikry, Osama Salama | Ano: 2020 | Database: pubmed
Resumo: Myrrh is the resinous exudate obtained by the incision in Commiphora molmol trees (Family Burseraceae). The bactericidal activity of its hexane extract was compared to its essential oil (MEO) using viable count technique against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (Ps. aeruginosa). MEO exhibited a better activity with > 99.999% killing of both tested strains after 2 h contact time. MEO was tested using the same technique against four multidrug resistant isolates: S. aureus (MRSA, sputum), Escherichia coli (E. coli, urine), Ps. aeruginosa (wound) and Klebsiella pneumonia (K. pneumonia, sputum). Highest bactericidal activity was observed against Ps. aeruginosa while lowest was against K. pneumonia (99.59 and 54.04% killing, respectively after 2 h contact time). A cream and mouthwash were formulated using 5% v/v MEO. The cream showed a better activity against Ps. aeruginosa than S. aureus (95.11 and 86.76% killing, respectively after 2 h contact time). The in vitro treatment of ca 107 CFU/ml S. aureus cells suspended in 10% saliva with the mouthwash produced ca 46% killing within the first 15 min reaching ca 99.999% after 30 min. Cytotoxic studies of both the essential oil and hexane extract on human liver cancer (Hep G2), human breast cancer (MCF-7) and colon cancer cell lines (HCT-116) revealed a promising in vitro activity. Highest activity was recorded for the essential oil on MCF-7 with IC50 10.93 ± 0.32 μg/ml. GC/MS analysis allowed the identification of 17 and 9 compounds representing 92.01 and 99.99% of the hexane extract and essential oil, respectively. Furano-eudesma-1,3-diene (15.99%) and 2-acetoxy-furano-diene (26.82%) were the major identified compounds in the hexane extract and essential oil, respectively. These results indicate that Myrrh essential oil is a promising antibacterial and cytotoxic agent that can be formulated in suitable dosage forms.
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Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi.
Autores: Jie Feng, Wanliang Shi, Judith Miklossy, Genevieve M Tauxe, Conor J McMeniman, Ying Zhang | Ano: 2018 | Database: pubmed
Resumo: Lyme disease is the most common vector borne-disease in the United States (US). While the majority of the Lyme disease patients can be cured with 2⁻4 weeks antibiotic treatment, about 10⁻20% of patients continue to suffer from persisting symptoms. While the cause of this condition is unclear, persistent infection was proposed as one possibility. It has recently been shown that B. burgdorferi develops dormant persisters in stationary phase cultures that are not killed by the current Lyme antibiotics, and there is interest in identifying novel drug candidates that more effectively kill such forms. We previously identified some highly active essential oils with excellent activity against biofilm and stationary phase B. burgdorferi. Here, we screened another 35 essential oils and found 10 essential oils (Allium sativum L. bulbs, Pimenta officinalis Lindl. berries, Cuminum cyminum L. seeds, Cymbopogon martini var. motia Bruno grass, Commiphora myrrha (T. Nees) Engl. resin, Hedychium spicatum Buch.-Ham. ex Sm. flowers, Amyris balsamifera L. wood, Thymus vulgaris L. leaves, Litsea cubeba (Lour.) Pers. fruits, Eucalyptus citriodora Hook. leaves) and the active component of cinnamon bark cinnamaldehyde (CA) at a low concentration of 0.1% have strong activity against stationary phase B. burgdorferi. At a lower concentration of 0.05%, essential oils of Allium sativum L. bulbs, Pimenta officinalis Lindl. berries, Cymbopogon martini var. motia Bruno grass and CA still exhibited strong activity against the stationary phase B. burgdorferi. CA also showed strong activity against replicating B. burgdorferi, with a MIC of 0.02% (or 0.2 μg/mL). In subculture studies, the top five essential oil hits Allium sativum L. bulbs, Pimenta officinalis Lindl. berries, Commiphora myrrha (T. Nees) Engl. resin, Hedychium spicatum Buch.-Ham. ex Sm. flowers, and Litsea cubeba (Lour.) Pers. fruits completely eradicated all B. burgdorferi stationary phase cells at 0.1%, while Cymbopogon martini var. motia Bruno grass, Eucalyptus citriodora Hook. leaves, Amyris balsamifera L. wood, Cuminum cyminum L. seeds, and Thymus vulgaris L. leaves failed to do so as shown by visible spirochetal growth after 21-day subculture. At concentration of 0.05%, only Allium sativum L. bulbs essential oil and CA sterilized the B. burgdorferi stationary phase culture, as shown by no regrowth during subculture, while Pimenta officinalis Lindl. berries, Commiphora myrrha (T. Nees) Engl. resin, Hedychium spicatum Buch.-Ham. ex Sm. flowers and Litsea cubeba (Lour.) Pers. fruits essential oils all had visible growth during subculture. Future studies are needed to determine if these highly active essential oils could eradicate persistent B. burgdorferi infection in vivo.
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Identification of essential oils with activity against stationary phase Staphylococcus aureus.
Autores: Shuzhen Xiao, Peng Cui, Wanliang Shi, Ying Zhang | Ano: 2020 | Database: pubmed
Resumo: Staphylococcus aureus is the most dominant human pathogen, responsible for a variety of chronic and severe infections. There is mounting evidence that persisters are associated with treatment failure and relapse of persistent infections. While some essential oils were reported to have antimicrobial activity against growing S. aureus, activity of essential oils against the stationary phase S. aureus enriched in persisters has not been investigated.
Resultados: We identified 39 essential oils (Oregano, Cinnamon bark, Thyme white, Bandit "Thieves", Lemongrass (Cymbopogon flexuosus), Sandalwood oil, Health shield, Allspice, Amyris, Palmarosa, Cinnamon leaf, Clove bud, Citronella, Geranium bourbon, Marjoram, Peppermint, Lemongrass, Cornmint, Elemi, Ho wood, Head ease, Lemon eucalyptus, Litsea cubeba, Myrrh, Parsley seed, Coriander oil, Dillweed, Hyssop, Neroli, Rosewood oil, Tea tree, Cajeput, Clove bud, Lavender, Sleep tight, Vetiver, Palo santo, Sage oil, Yarrow) at 0.5% (v/v) concentration, 10 essential oils (Cinnamon bark, Oregano, Thyme white, Bandit "Thieves", Lemongrass, Sandalwood oil, Health shield, Allspice, Amyris, Palmarosa at 0.25% (v/v) concentration, and 7 essential oils (Oregano, Cinnamon bark, Thyme white, Lemongrass, Allspice, Amyris, Palmarosa at 0.125% (v/v) concentration to have high activity against stationary phase S. aureus with no visible growth on agar plates after five-day exposure. Among the 10 essential oils which showed high activity at 0.25% (v/v) concentration, 9 (Oregano, Cinnamon bark, Thyme white, Bandit "Thieves", Lemongrass, Health shield, Allspice, Palmarosa, Amyris showed higher activity than the known persister drug tosufloxacin, while Sandalwood oil had activity at a higher concentration. In Oregano essential oil combination studies with antibiotics, Oregano plus tosufloxacin (or levofloxacin, ciprofloxacin) and rifampin completely eradicated stationary phase S. aureus cells, but had no apparent enhancement for linezolid, vancomycin, sulfamethoxazole, trimethoprim, azithromycin or gentamicin.
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Buffalo Yogurt Fortified with Eucalyptus (Eucalyptus camaldulensis) and Myrrh (Commiphora Myrrha) Essential Oils: New Insights into the Functional Properties and Extended Shelf Life.
Autores: Ahmed Mohamed Hamed, Awad A Awad, Ahmed E Abdel-Mobdy, Abdulhakeem Alzahrani, Ahmad Mohammad Salamatullah | Ano: 2021 | Database: pubmed
Resumo: Eucalyptus (Eucalyptus camaldulensis) and Myrrh (Commiphora Myrrha) essential oils (EOs) stand out for their benefits in terms of health and functionality. Buffalo set yogurt enriched with different concentrations of EOs (0.3, 0.6, and 0.9%) were investigated. The effects of addition on sensory, syneresis, antibacterial activity, and bioactive properties (total phenol content and antioxidant activity) of yogurt were studied. The most acceptable organoleptic properties of treated yogurt were those samples treated with Eucalyptus oil. The levels of syneresis were decreased by increasing the concentration of EOs. Moreover, the antioxidant activity, antibacterial activity, and total phenolic content were enhanced by increasing the concentration of EOs. Yogurt with 0.9% Eucalyptus oil showed the highest antioxidant activity and total phenolic content. The same concentration of Eucalyptus oil showed the highest antibacterial activity against S. typhimurium (the inhibition zone was 20.63 mm) then E. coli (the inhibition zone was 19.43 mm). On the other hand, the highest antibacterial effect against L. monocytogene was for Myrrh oil-enriched yogurt by 0.9% and the inhibition zone was 19.21 mm. The obtained results showed that Eucalyptus and Myrrh oils can be applied to yogurt to improve its beneficial properties in terms of physical characteristics and for human health due to their antioxidant activity and phenolic materials.
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Buffalo Yogurt Fortified with Eucalyptus (Eucalyptus camaldulensis) and Myrrh (Commiphora Myrrha) Essential Oils: New Insights into the Functional Properties and Extended Shelf Life.
Autores: Ahmed Mohamed Hamed, Awad A Awad, Ahmed E Abdel-Mobdy, Abdulhakeem Alzahrani, Ahmad Mohammad Salamatullah | Ano: 2021 | Database: pubmed
Resumo: Eucalyptus (Eucalyptus camaldulensis) and Myrrh (Commiphora Myrrha) essential oils (EOs) stand out for their benefits in terms of health and functionality. Buffalo set yogurt enriched with different concentrations of EOs (0.3, 0.6, and 0.9%) were investigated. The effects of addition on sensory, syneresis, antibacterial activity, and bioactive properties (total phenol content and antioxidant activity) of yogurt were studied. The most acceptable organoleptic properties of treated yogurt were those samples treated with Eucalyptus oil. The levels of syneresis were decreased by increasing the concentration of EOs. Moreover, the antioxidant activity, antibacterial activity, and total phenolic content were enhanced by increasing the concentration of EOs. Yogurt with 0.9% Eucalyptus oil showed the highest antioxidant activity and total phenolic content. The same concentration of Eucalyptus oil showed the highest antibacterial activity against S. typhimurium (the inhibition zone was 20.63 mm) then E. coli (the inhibition zone was 19.43 mm). On the other hand, the highest antibacterial effect against L. monocytogene was for Myrrh oil-enriched yogurt by 0.9% and the inhibition zone was 19.21 mm. The obtained results showed that Eucalyptus and Myrrh oils can be applied to yogurt to improve its beneficial properties in terms of physical characteristics and for human health due to their antioxidant activity and phenolic materials.
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A Comprehensive in vitro and in silico Analysis of Nematicidal Action of Essential Oils.
Autores: Aditi Kundu, Anirban Dutta, Abhishek Mandal, Lalit Negi, Monika Malik, Rajshekhar Puramchatwad, Jyoti Antil, Anupama Singh, Uma Rao, Supradip Saha, Rajesh Kumar, Neeraj Patanjali, Suman Manna, Anil Kumar, Sukanta Dash, P K Singh | Ano: 2020 | Database: pubmed
Resumo: Nematicidal potential of essential oils (EOs) has been widely reported. Terpenoids present in most of the essential oils have been reported responsible for their bioactivity though very less is known about their modes of action. In the present study, an in vitro screening of nine Eos, namely, Citrus sinensis (OEO), Myrtus communis (MTEO), Eucalyptus citriodora (CEO), Melaleuca alternifolia (TEO), Acorus calamus (AEO), Commiphora myrrha (MREO), Cymbopogon nardus (CNEO), Artemisia absinthium (WEO), and Pogostemon cablin (PEO) against Meloidogyne incognita revealed OEO, CNEO, and TEO as most effective with LC50 39.37, 43.22, and 76.28 μg ml-1 respectively. EOs had varying compositions of mono- and sesquiterpenes determined by gas chromatography-mass spectrometry (GC-MS) analysis. The in silico molecular interactions screening of major EO constituents and the seven selected target proteins of the nematode indicated highest binding affinity of geraniol-ODR1 (odorant response gene 1) complex (ΔG = -36.9 kcal mol-1), due to extensive H-bonding, hydrophobic and π-alkyl interactions. The relative binding affinity followed the order: geraniol-ODR1 > β-terpineol-ODR1 > citronellal-ODR1 > l-limonene-ODR1 > γ-terpinene-ODR1. Taken together, the cumulative in vitro and computational bioefficacy analysis related to the chemoprofiles of EOs provides useful leads on harnessing the potential of EOs as bionematicides. The insight on biochemical ligand-target protein interactions described in the present work will be helpful in logical selection of biomolecules and essential oils for development of practically viable bionematicidal products.
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Assessment and Characterization of Some New Photosensitizers for Antimicrobial Photodynamic Therapy (aPDT).
Autores: Laura Monica Dascalu Rusu, Marioara Moldovan, Doina Prodan, Irina Ciotlaus, Violeta Popescu, Ioana Baldea, Rahela Carpa, Sorina Sava, Radu Chifor, Mindra Eugenia Badea | Ano: 2020 | Database: pubmed
Resumo: The novelty of this study consists on the formulation and evaluation of five complex experimental natural photosensitizers (PS): gel with oregano essential oil (O), gel with methylene blue (AM), gel with a mixture of essential oils (Thieves-H), gel with arnica oil and curcuma extract (CU) and gel with frankincense essential oil (T), used as photosensitizing agents (PS) in antimicrobial photodynamic therapy (aPDT) in the control of microbial biofilm in oral cavity. The experimental PS were characterized by gas chromatography-mass spectrometry (GC-MS), Fourier-transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, cytotoxicity assay, antimicrobial effect and scanning electron microscopy (SEM). The IR spectra of the experimental PS with essential oils exhibit absorption bands due to the presence of water and glycerol in high quantities. The studied compounds had a reduced cytotoxic effect on cell cultures. The lowest cytotoxic effect was observed in experimental PS with oregano essential oil and methylene blue PS. Essential oils with proven antibacterial capabilities used in experimental PS confer antibacterial activity to the gels in which they are incorporated, an activity that may be more efficient use of a PDT therapy. Single bacteria were detected mainly by SEM after 12 h, while aggregate bacteria and micro colonies dominated the samples at 48 h.
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Chemical composition of the essential oil and supercritical CO2 extract of Commiphora myrrha (Nees) Engl. and of Acorus calamus L.
Autores: Bruno Marongiu, Alessandra Piras, Silvia Porcedda, Andrea Scorciapino | Ano: 2005 | Database: pubmed
Resumo: Volatile concentrates from the oleo-gum resin of Commiphora myrrha (Nees) Engl. and from the rhizomes of Acorus calamus were isolated by supercritical extraction with carbon dioxide. The volatile oil of myrrh was obtained at 9.0 MPa and 50 degrees C and at a CO2 flow of 1.5 kg/h. Acorus calamus was extracted at 9.0 MPa and 45 degrees C and at a CO2 flow of 1.6 kg/h. In both cases, an oil devoid of cuticular waxes was obtained with a single depressurization stage. The SFE myrrh oil had a yield, Y, of 3.2%. Its main components, identified and quantified by GC/MS, were furanoeudesma-1,3-diene, 34.9%; lindestrene, 12.9%; curzerene, 8.5%; and germacrone, 5.8%. The essential oils from the same starting material by hydrodistillation, HD, (Y = 2.8%) and by steam distillation, SD, (Y = 0.4%) were quite similar to the SFE extract. The main components of the SFE oil of A. calamus (Y = 3.5%) were acorenone, 13.4%; iso-acorone, 11.6%; (Z)-sesquilavandulol, 11.0%; dehydroxy isocalamendiol, 7.7%; and beta-asarone, 5.5%. The comparison with hydrodistilled (Y = 1.8%) and steam distilled (Y = 1.0%) oils revealed large differences in the content of iso-acorone and crypto-acorone.
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In vitro cytogenotoxic and mutagenic effects of Commiphora myrrha essential oil.
Autores: Amine Hafis Abdelsalam, Hasan Basri Ila | Ano: 2022 | Database: pubmed
Resumo: Commiphora myrrha, located in the tropical zone, is a widely used tree for medicinal purposes in the Arabian Peninsula and a large part of Africa. In this research, cytogenotoxic effects of the commercially available Commiphora myrrha essential oil (myrrh) were studied using micronucleus (MN), comet, and total oxidant (TOS), and total antioxidant (TAS) assays on human peripheral lymphocytes under in vitro conditions. In addition, pure pBR322 plasmid DNA was used to investigate DNA damaging/protecting activity of the essential oil. Finally, a bacterial reversion (Ames) test was performed using Salmonella typhimurium mutant strains TA98 and TA100 to determine the potential effect of the agent in the induction of gene mutations. The high concentration of Commiphora myrrha (0.125 µL/mL) induced MN formation significantly compared to the untreated control in both treatment times (24 or 48 h). Only at the highest concentration, nuclear division index (NDI) values were found lower than the controls. In the Comet test performed on healthy lymphocytes, only the highest concentration of myrrh caused significant increases in the percentage of damaged cells and genetic damage index (GDI) values. Myrrh oil showed no significant mutagenic effect on mutant Salmonella strains. In addition, the substance did not directly damage plasmid DNA but also protected DNA against damaging factors such as H2O2 and UV. Finally, in the TAS and TOS assays, no significant differences on the oxidative stress parameters were found in cell culture compared to the control. The results of this study showed that myrrh oil exerts cytogenotoxic risk only at higher concentrations.
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Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil.
Autores: Feng Shi, Ji-Hui Zhao, Ying Liu, Zhi Wang, Yong-Tai Zhang, Nian-Ping Feng | Ano: 2012 | Database: pubmed
Resumo: The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the oral delivery of frankincense and myrrh essential oils (FMO). Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE) were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM). The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 ± 3.6 nm, a ZP of -16.8 ± 0.4 mV, and an EE of 80.60% ± 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.
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Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh).
Autores: A Massoud, S El Sisi, O Salama, A Massoud | Ano: 2001 | Database: pubmed
Resumo: Myrrh (from the stem of the Commiphora molmol tree) is an oleo gum resin that may prove efficacious for the treatment of fascioliasis. We studied 7 patients who were passing Fasciola eggs in their stools and treated them with myrrh. The drug (a formulation consisting of 8 parts of resin and 3.5 parts of volatile oils, all extracted from myrrh) was given in a dose of 12 mg/kg per day for 6 consecutive days in the morning on an empty stomach. Patients were followed for 3 months. The therapy proved to be effective, with pronounced improvement of the general condition and amelioration of all symptoms and signs. A dramatic drop in the egg count was detected at the end of treatment. Eggs were no longer detectable in the feces 3 weeks after treatment and after a follow-up period of 3 months. High eosinophilic counts, elevated liver enzymes, and Fasciola antibody titers returned to nearly normal. No signs of toxicity or adverse effects were observed. We conclude that the formulation of myrrh is safe, well tolerated, and effective for treating fascioliasis.
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Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh).
Autores: A Massoud, S El Sisi, O Salama, A Massoud | Ano: 2001 | Database: pubmed
Resumo: Myrrh (from the stem of the Commiphora molmol tree) is an oleo gum resin that may prove efficacious for the treatment of fascioliasis. We studied 7 patients who were passing Fasciola eggs in their stools and treated them with myrrh. The drug (a formulation consisting of 8 parts of resin and 3.5 parts of volatile oils, all extracted from myrrh) was given in a dose of 12 mg/kg per day for 6 consecutive days in the morning on an empty stomach. Patients were followed for 3 months. The therapy proved to be effective, with pronounced improvement of the general condition and amelioration of all symptoms and signs. A dramatic drop in the egg count was detected at the end of treatment. Eggs were no longer detectable in the feces 3 weeks after treatment and after a follow-up period of 3 months. High eosinophilic counts, elevated liver enzymes, and Fasciola antibody titers returned to nearly normal. No signs of toxicity or adverse effects were observed. We conclude that the formulation of myrrh is safe, well tolerated, and effective for treating fascioliasis.
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A Comprehensive in vitro and in silico Analysis of Nematicidal Action of Essential Oils.
Autores: Aditi Kundu, Anirban Dutta, Abhishek Mandal, Lalit Negi, Monika Malik, Rajshekhar Puramchatwad, Jyoti Antil, Anupama Singh, Uma Rao, Supradip Saha, Rajesh Kumar, Neeraj Patanjali, Suman Manna, Anil Kumar, Sukanta Dash, P K Singh | Ano: 2020 | Database: pubmed
Resumo: Nematicidal potential of essential oils (EOs) has been widely reported. Terpenoids present in most of the essential oils have been reported responsible for their bioactivity though very less is known about their modes of action. In the present study, an in vitro screening of nine Eos, namely, Citrus sinensis (OEO), Myrtus communis (MTEO), Eucalyptus citriodora (CEO), Melaleuca alternifolia (TEO), Acorus calamus (AEO), Commiphora myrrha (MREO), Cymbopogon nardus (CNEO), Artemisia absinthium (WEO), and Pogostemon cablin (PEO) against Meloidogyne incognita revealed OEO, CNEO, and TEO as most effective with LC50 39.37, 43.22, and 76.28 μg ml-1 respectively. EOs had varying compositions of mono- and sesquiterpenes determined by gas chromatography-mass spectrometry (GC-MS) analysis. The in silico molecular interactions screening of major EO constituents and the seven selected target proteins of the nematode indicated highest binding affinity of geraniol-ODR1 (odorant response gene 1) complex (ΔG = -36.9 kcal mol-1), due to extensive H-bonding, hydrophobic and π-alkyl interactions. The relative binding affinity followed the order: geraniol-ODR1 > β-terpineol-ODR1 > citronellal-ODR1 > l-limonene-ODR1 > γ-terpinene-ODR1. Taken together, the cumulative in vitro and computational bioefficacy analysis related to the chemoprofiles of EOs provides useful leads on harnessing the potential of EOs as bionematicides. The insight on biochemical ligand-target protein interactions described in the present work will be helpful in logical selection of biomolecules and essential oils for development of practically viable bionematicidal products.
Resultados: N/A
Conclusão: N/A
Irritant potential of some constituents from oleo-gum-resin of Commiphora myrrha.
Autores: M Asif Saeed, A W Sabir | Ano: 2004 | Database: pubmed
Resumo: The irritant potentials of essential oil and seven sesquiterpenoids compounds newly isolated from the oleo-gum-resin of Commiphora myrrha were investigated by open mouse ear assay. The essential oil, curzerenone, furanodiene-6-one and furanoeudesma-1,3-diene showed potent and persistent irritant effects while others possess least irritant potentials.
Resultados: N/A
Conclusão: N/A
Protective effects of myrrh essential oil on isoproterenol-induced myocardial infarction in rats through antioxidant, anti-inflammatory, Nrf2/HO-1 and apoptotic pathways.
Autores: Nancy S Younis, Maged E Mohamed | Ano: 2021 | Database: pubmed
Resumo: Myrrh, a traditional remedy, is the stem resinous exudate of Commiphora molmol Engler (Burseraceae). The aromatic yellowish-brown oleoresin has a long history in folk and traditional medicine, in Saudi Arabia and the Arab world. Severe universal concern attributable to the high mortality is Myocardial Infarction (MI). Acute administration of Isoproterenol (ISO) is an established animal model to induce myocardial injury.
Resultados: Animals experienced MI displayed functional blood pressure deviations, intensification in the heart to body weight ratio, myocytes indicative markers (CK-MB, CPK, LDH, cTnT, cTnI), lipid peroxidation (MDA), protein expression of Nrf2 and HO-1, apoptotic markers (Caspase 3,9), and inflammatory indicators. Conversely, animals pre-treated with Myrrh revealed obliteration of those elevations triggered by ISO induction, diminished elevated biochemical values and improved heart function.
Conclusão: Myrrh abstain effective cardio-protective action in MI model through improving the oxidative condition with myocytes and abolishing apoptotic as well as inflammatory responses.
Protection against singlet oxygen, the main actor of sebum squalene peroxidation during sun exposure, using Commiphora myrrha essential oil.
Autores: B Auffray | Ano: 2007 | Database: pubmed
Resumo: Squalene is a component of sebum. Both are directly exposed to the external environment and play a key role in skin physiology. They are particularly prone to photo oxidation during sun exposure. We studied the impact of two types of antioxidant on sebum squalene peroxidation by UV irradiation. The first type is free radical scavenger (Butyl hydroxyl toluene and an olive extract rich in hydroxytyrosol). The second type is the essential oil of Commipora myrrha, a singlet oxygen quencher. These properties were confirmed using the 2,2-diphenyl-1-picrylhydrazyl test for antiradical capacity [Yoshida et al. (1989) Chem. Pharm. Bull., 37, 1919; Buenger et al. (2006) Int. J. Cosmet. Sci., 28, 135] and 1,3-diphenylisobenzofuran test for the capacity to quench singlet oxygen [Kochewar and Redmond (2000) Meth. Enzymol., 28, 319; Racine and Auffray (2005) Fitoterapia, 76, 316]. Furthermore, we have extended an ex vivo method to classify the efficacy of cosmetics to protect squalene by collecting sebum in vivo and irradiating it in a controlled way. The squalene monohydroperoxide formation is monitored by high performance liquid chromatography. This methods allows us to compare the efficiency of the three antioxidants at 0.6% in a cosmetic formulation to protect squalene from photo oxidation. Our results clearly show that essential oil of Commiphora myrrha provides the best protection against squalene peroxidation. These results demonstrate that squalene peroxidation during solar exposure is mainly because of singlet oxygen and not due to free radical attack. This suggests that sun care cosmetics should make use not only of free radical scavengers but also of singlet oxygen quenchers.
Resultados: N/A
Conclusão: N/A
Myrrh Essential Oil Mitigates Renal Ischemia/Reperfusion-Induced Injury.
Autores: Nancy S Younis | Ano: 2023 | Database: pubmed
Resumo: Ischemia/reperfusion (I/R)-induced renal injury is a common reason for kidney injury in clinical settings; therefore, continuous investigation of novel nephroprotective agents is crucial. Myrrh, the oleoresin exudates generated by the genus Commiphora, display numerous pharmacological actions. This study tried to assess the preventive effects of myrrh essential oil against I/R-induced renal damage.
Resultados: Serum levels of renal function tests and renal injury biomarkers, including NGAL, KIM-1, and CysC, were amplified in the renal I/R group. Animals that experienced renal I/R exhibited elevated lipid peroxidation (MDA); declined SOD, CAT, and GPx activity; declined GSH content; augmented TLR4/NFκB gene expression; and subsequent enhancement of inflammatory mediators (TNF-α, IFN-γ, IL-1β, and IL-6). Myrrh reduced renal function tests and injury biomarkers and amended renal histological alterations. Pretreatment with myrrh reduced MDA, elevated the antioxidant enzymes' activities and GSH content, and reduced the TLR4 and NFκB gene expression, leading to subsequent inflammation and apoptosis alleviation.
Conclusão: N/A
Myrrh Essential Oil Mitigates Renal Ischemia/Reperfusion-Induced Injury.
Autores: Nancy S Younis | Ano: 2023 | Database: pubmed
Resumo: Ischemia/reperfusion (I/R)-induced renal injury is a common reason for kidney injury in clinical settings; therefore, continuous investigation of novel nephroprotective agents is crucial. Myrrh, the oleoresin exudates generated by the genus Commiphora, display numerous pharmacological actions. This study tried to assess the preventive effects of myrrh essential oil against I/R-induced renal damage.
Resultados: Serum levels of renal function tests and renal injury biomarkers, including NGAL, KIM-1, and CysC, were amplified in the renal I/R group. Animals that experienced renal I/R exhibited elevated lipid peroxidation (MDA); declined SOD, CAT, and GPx activity; declined GSH content; augmented TLR4/NFκB gene expression; and subsequent enhancement of inflammatory mediators (TNF-α, IFN-γ, IL-1β, and IL-6). Myrrh reduced renal function tests and injury biomarkers and amended renal histological alterations. Pretreatment with myrrh reduced MDA, elevated the antioxidant enzymes' activities and GSH content, and reduced the TLR4 and NFκB gene expression, leading to subsequent inflammation and apoptosis alleviation.
Conclusão: N/A
Tabela de propriedades
| Óleo Essencial | Propriedade | Confirmado | Título | Autores | Ano | Database | Link |
|---|---|---|---|---|---|---|---|
| Mirra | Antimicrobiana | Sim | Components, therapeutic value and uses of myrrh. | E S H El Ashry, N Rashed, O M Salama, A Saleh | 2003 | pubmed | N/A |
| Mirra | Antimicrobiano | Sim | Components, therapeutic value and uses of myrrh. | E S H El Ashry, N Rashed, O M Salama, A Saleh | 2003 | pubmed | N/A |
| Mirra | Antisséptica, anestésica e antitumoral | Sim | Myrrh: medical marvel or myth of the Magi? | Effie Y H Nomicos | 2007 | pubmed | N/A |
| Mirra | Atividade Antifúngica contra Candida spp. | Sim | Sensitivity of clinical isolates of Candida to essential oils from Burseraceae family. | Miloš Nikolic, Marija Smiljkovic, Tatjana Markovic, Ana Cirica, Jasmina Glamoclija, Dejan Markovic, Marina Sokovic | 2016 | pubmed | N/A |
| Mirra | Atividade Antimicrobiana | Sim | The additive and synergistic antimicrobial effects of select frankincense and myrrh oils--a combination from the pharaonic pharmacopoeia. | S de Rapper, S F Van Vuuren, G P P Kamatou, A M Viljoen, E Dagne | 2012 | pubmed | N/A |
| Mirra | Atividade antibacteriana | Sim | Chemical composition and antibacterial activity of selected essential oils and some of their main compounds. | Juergen Wanner, Erich Schmidt, Stefanie Bail, Leopold Jirovetz, Gerhard Buchbauer, Velizar Gochev, Tanya Girova, Teodora Atanasova, Albena Stoyanova | 2010 | pubmed | N/A |
| Mirra | Atividade antimicrobiana de amplo espectro contra cinco cepas de microrganismos de feridas | Sim | Wound Pathogens: Investigating Antimicrobial Activity of Commercial Essential Oil Combinations against Reference Strains. | Ané Orchard, Alvaro Viljoen, Sandy van Vuuren | 2018 | pubmed | N/A |
| Mirra | Atividade bactericida contra Staphylococcus aureus e Pseudomonas aeruginosa | Sim | Bactericidal activity of Myrrh extracts and two dosage forms against standard bacterial strains and multidrug-resistant clinical isolates with GC/MS profiling. | Noha Khalil, Sahar Fikry, Osama Salama | 2020 | pubmed | N/A |
| Mirra | Atividade contra a fase estacionária da Borrelia burgdorferi | Sim | Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi. | Jie Feng, Wanliang Shi, Judith Miklossy, Genevieve M Tauxe, Conor J McMeniman, Ying Zhang | 2018 | pubmed | N/A |
| Mirra | Atividade contra a fase estacionária de Staphylococcus aureus. | Sim | Identification of essential oils with activity against stationary phase Staphylococcus aureus. | Shuzhen Xiao, Peng Cui, Wanliang Shi, Ying Zhang | 2020 | pubmed | N/A |
| Mirra | Aumento da atividade antioxidante e antibacteriana, diminuição da sinerese em iogurte de búfala fortificado. | Sim | Buffalo Yogurt Fortified with Eucalyptus (Eucalyptus camaldulensis) and Myrrh (Commiphora Myrrha) Essential Oils: New Insights into the Functional Properties and Extended Shelf Life. | Ahmed Mohamed Hamed, Awad A Awad, Ahmed E Abdel-Mobdy, Abdulhakeem Alzahrani, Ahmad Mohammad Salamatullah | 2021 | pubmed | N/A |
| Mirra | Aumento da atividade antioxidante, atividade antibacteriana e conteúdo fenólico total em iogurte enriquecido | Sim | Buffalo Yogurt Fortified with Eucalyptus (Eucalyptus camaldulensis) and Myrrh (Commiphora Myrrha) Essential Oils: New Insights into the Functional Properties and Extended Shelf Life. | Ahmed Mohamed Hamed, Awad A Awad, Ahmed E Abdel-Mobdy, Abdulhakeem Alzahrani, Ahmad Mohammad Salamatullah | 2021 | pubmed | N/A |
| Mirra | Ação nematicida em Meloidogyne incognita | Sim | A Comprehensive in vitro and in silico Analysis of Nematicidal Action of Essential Oils. | Aditi Kundu, Anirban Dutta, Abhishek Mandal, Lalit Negi, Monika Malik, Rajshekhar Puramchatwad, Jyoti Antil, Anupama Singh, Uma Rao, Supradip Saha, Rajesh Kumar, Neeraj Patanjali, Suman Manna, Anil Kumar, Sukanta Dash, P K Singh | 2020 | pubmed | N/A |
| Mirra | Capacidade antibacteriana. | Sim | Assessment and Characterization of Some New Photosensitizers for Antimicrobial Photodynamic Therapy (aPDT). | Laura Monica Dascalu Rusu, Marioara Moldovan, Doina Prodan, Irina Ciotlaus, Violeta Popescu, Ioana Baldea, Rahela Carpa, Sorina Sava, Radu Chifor, Mindra Eugenia Badea | 2020 | pubmed | N/A |
| Mirra | Composição química do óleo essencial | Sim | Chemical composition of the essential oil and supercritical CO2 extract of Commiphora myrrha (Nees) Engl. and of Acorus calamus L. | Bruno Marongiu, Alessandra Piras, Silvia Porcedda, Andrea Scorciapino | 2005 | pubmed | N/A |
| Mirra | Efeito citogenotóxico | Sim | In vitro cytogenotoxic and mutagenic effects of Commiphora myrrha essential oil. | Amine Hafis Abdelsalam, Hasan Basri Ila | 2022 | pubmed | N/A |
| Mirra | Entrega oral de óleos essenciais encapsulados em nanopartículas sólidas | Sim | Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil. | Feng Shi, Ji-Hui Zhao, Ying Liu, Zhi Wang, Yong-Tai Zhang, Nian-Ping Feng | 2012 | pubmed | N/A |
| Mirra | Fasciculocida | Sim | Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh). | A Massoud, S El Sisi, O Salama, A Massoud | 2001 | pubmed | N/A |
| Mirra | Fasciolicida | Sim | Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh). | A Massoud, S El Sisi, O Salama, A Massoud | 2001 | pubmed | N/A |
| Mirra | Nematicida | Sim | A Comprehensive in vitro and in silico Analysis of Nematicidal Action of Essential Oils. | Aditi Kundu, Anirban Dutta, Abhishek Mandal, Lalit Negi, Monika Malik, Rajshekhar Puramchatwad, Jyoti Antil, Anupama Singh, Uma Rao, Supradip Saha, Rajesh Kumar, Neeraj Patanjali, Suman Manna, Anil Kumar, Sukanta Dash, P K Singh | 2020 | pubmed | N/A |
| Mirra | Potencial irritante | Sim | Irritant potential of some constituents from oleo-gum-resin of Commiphora myrrha. | M Asif Saeed, A W Sabir | 2004 | pubmed | N/A |
| Mirra | Protetor cardiovascular | Sim | Protective effects of myrrh essential oil on isoproterenol-induced myocardial infarction in rats through antioxidant, anti-inflammatory, Nrf2/HO-1 and apoptotic pathways. | Nancy S Younis, Maged E Mohamed | 2021 | pubmed | N/A |
| Mirra | Proteção contra a peroxidação do esqualeno presente no sebo durante a exposição solar | Sim | Protection against singlet oxygen, the main actor of sebum squalene peroxidation during sun exposure, using Commiphora myrrha essential oil. | B Auffray | 2007 | pubmed | N/A |
| Mirra | Proteção contra lesão renal induzida por isquemia/reperfusão | Sim | Myrrh Essential Oil Mitigates Renal Ischemia/Reperfusion-Induced Injury. | Nancy S Younis | 2023 | pubmed | N/A |
| Mirra | Proteção do Rim contra Isquemia/Reperfusão | Sim | Myrrh Essential Oil Mitigates Renal Ischemia/Reperfusion-Induced Injury. | Nancy S Younis | 2023 | pubmed | N/A |